Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3729360..3730083 Replicon chromosome
Accession NZ_CP101595
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NNQ27_RS17960 Protein ID WP_275885108.1
Coordinates 3729360..3729680 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NNQ27_RS17965 Protein ID WP_275885109.1
Coordinates 3729748..3730083 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS17935 (NNQ27_17935) 3725040..3726884 + 1845 WP_007727072.1 RNA polymerase sigma factor RpoD -
NNQ27_RS17940 (NNQ27_17940) 3727136..3727555 + 420 WP_275885106.1 hypothetical protein -
NNQ27_RS17945 (NNQ27_17945) 3727602..3728108 - 507 WP_007752318.1 G/U mismatch-specific DNA glycosylase -
NNQ27_RS17955 (NNQ27_17955) 3728413..3729246 - 834 WP_275885107.1 DUF4942 domain-containing protein -
NNQ27_RS17960 (NNQ27_17960) 3729360..3729680 - 321 WP_275885108.1 TA system toxin CbtA family protein Toxin
NNQ27_RS17965 (NNQ27_17965) 3729748..3730083 - 336 WP_275885109.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NNQ27_RS17970 (NNQ27_17970) 3730098..3730577 - 480 WP_275885110.1 DNA repair protein RadC -
NNQ27_RS17975 (NNQ27_17975) 3730950..3731087 - 138 Protein_3503 transposase -
NNQ27_RS17980 (NNQ27_17980) 3731237..3732364 + 1128 WP_275885111.1 ATP-binding protein -
NNQ27_RS17985 (NNQ27_17985) 3732369..3732917 + 549 WP_059384886.1 helix-turn-helix domain-containing protein -
NNQ27_RS17990 (NNQ27_17990) 3733054..3734145 + 1092 WP_275885112.1 multiubiquitin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3728413..3760599 32186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12070.72 Da        Isoelectric Point: 5.0359

>T252368 WP_275885108.1 NZ_CP101595:c3729680-3729360 [Cronobacter dublinensis]
MQISTVPATLPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHEDAAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12561.26 Da        Isoelectric Point: 6.7394

>AT252368 WP_275885109.1 NZ_CP101595:c3730083-3729748 [Cronobacter dublinensis]
MNKDVTQTWGLKRDITPCFGARLVQEGHRLHFLADRAGFNGSFSEMRARDLDEAFPHFVTHMELMLLSGELNPRCGHCVT
LYRNGLTCEADTLGSHGYVYIAIYPSNQVKD

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References