Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2951027..2951672 Replicon chromosome
Accession NZ_CP101595
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NNQ27_RS14285 Protein ID WP_275884859.1
Coordinates 2951310..2951672 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NNQ27_RS14280 Protein ID WP_007750247.1
Coordinates 2951027..2951323 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS14270 (NNQ27_14280) 2948685..2949533 - 849 WP_275884857.1 DNA-3-methyladenine glycosylase 2 -
NNQ27_RS14275 (NNQ27_14285) 2949669..2951021 + 1353 WP_275884858.1 molecular chaperone -
NNQ27_RS14280 (NNQ27_14290) 2951027..2951323 - 297 WP_007750247.1 XRE family transcriptional regulator Antitoxin
NNQ27_RS14285 (NNQ27_14295) 2951310..2951672 - 363 WP_275884859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNQ27_RS14290 (NNQ27_14300) 2951902..2953143 + 1242 WP_105636316.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
NNQ27_RS14295 (NNQ27_14305) 2953143..2956265 + 3123 WP_275884860.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14009.10 Da        Isoelectric Point: 9.8453

>T252366 WP_275884859.1 NZ_CP101595:c2951672-2951310 [Cronobacter dublinensis]
MTWTVIFTPRFYEWYQQQPEGLQDRIAALLWNLRHSGPLVGRPLVDTIKGSQIPNLKELRVQYGGSPWRVFFAFDPTRQA
VVLCAGNKRGHKDFYKTLIRQAEDAFFLHLQIMESKNENA

Download         Length: 363 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10851.77 Da        Isoelectric Point: 5.8787

>AT252366 WP_007750247.1 NZ_CP101595:c2951323-2951027 [Cronobacter dublinensis]
MKTLDDVMAAFTPERQAEILRMADEIALEHGLPRLREERAFSQQQLAALMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLVELPEGSKVIPV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References