Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1052007..1052614 Replicon plasmid pB
Accession NZ_CP101519
Organism Ensifer adhaerens strain NER9

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MYG64_RS32690 Protein ID WP_192358711.1
Coordinates 1052007..1052261 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MYG64_RS32695 Protein ID WP_192358658.1
Coordinates 1052258..1052614 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG64_RS32670 (MYG64_32530) 1048161..1048397 + 237 WP_060607017.1 hypothetical protein -
MYG64_RS32675 (MYG64_32535) 1048546..1049640 + 1095 WP_112773196.1 PHB depolymerase family esterase -
MYG64_RS32680 (MYG64_32540) 1049888..1050655 - 768 WP_134888037.1 hypothetical protein -
MYG64_RS32685 (MYG64_32545) 1051198..1051722 - 525 WP_159416316.1 response regulator -
MYG64_RS32690 (MYG64_32550) 1052007..1052261 + 255 WP_192358711.1 type II toxin-antitoxin system HicA family toxin Toxin
MYG64_RS32695 (MYG64_32555) 1052258..1052614 + 357 WP_192358658.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MYG64_RS32700 (MYG64_32560) 1052861..1053514 - 654 WP_192358655.1 hypothetical protein -
MYG64_RS32705 (MYG64_32565) 1053817..1054077 - 261 WP_255381483.1 hypothetical protein -
MYG64_RS32710 (MYG64_32570) 1054295..1054537 - 243 WP_034800461.1 hypothetical protein -
MYG64_RS32715 (MYG64_32575) 1054976..1055512 + 537 WP_051659551.1 YidB family protein -
MYG64_RS32720 (MYG64_32580) 1055654..1056574 - 921 WP_255381487.1 adenylate/guanylate cyclase domain-containing protein -
MYG64_RS32725 (MYG64_32585) 1056832..1057134 - 303 WP_162741325.1 DUF982 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1586769 1586769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(26-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9321.69 Da        Isoelectric Point: 9.0806

>T252195 WP_192358711.1 NZ_CP101519:1052007-1052261 [Ensifer adhaerens]
MNGKQKKTLVAVFKDPVSGTIEWAGIENLLVAAGANVIERNGSRVKFEKDGIIASFHRPHPDKEAKRYQVCDAREFLTQI
GVEP

Download         Length: 255 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13017.57 Da        Isoelectric Point: 4.9676

>AT252195 WP_192358658.1 NZ_CP101519:1052258-1052614 [Ensifer adhaerens]
MNTMTYNGYHARIEFDAEDELFVGKIAGISDVVGFHGDSVSELKKAFHEAVDDYLETCKSIGKEPQRPYSGKMMFRVAPE
VHRRASLAAELSGKSLNQWAEEALDEAAAHVAEARLSA

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References