Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 734961..735502 Replicon plasmid pB
Accession NZ_CP101519
Organism Ensifer adhaerens strain NER9

Toxin (Protein)


Gene name parE Uniprot ID A0A1H0CJK8
Locus tag MYG64_RS31205 Protein ID WP_034798189.1
Coordinates 735209..735502 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1H0CJP6
Locus tag MYG64_RS31200 Protein ID WP_034798187.1
Coordinates 734961..735209 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG64_RS31190 (MYG64_31070) 730489..733182 + 2694 WP_255382289.1 TonB-dependent receptor -
MYG64_RS31195 (MYG64_31075) 733233..734717 - 1485 WP_060607839.1 MDR family MFS transporter -
MYG64_RS31200 (MYG64_31080) 734961..735209 + 249 WP_034798187.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MYG64_RS31205 (MYG64_31085) 735209..735502 + 294 WP_034798189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYG64_RS31210 (MYG64_31090) 735574..737013 - 1440 WP_159416141.1 NAD-dependent succinate-semialdehyde dehydrogenase -
MYG64_RS31215 (MYG64_31095) 737240..738178 - 939 WP_060521191.1 LysR family transcriptional regulator -
MYG64_RS31220 (MYG64_31100) 738274..738522 + 249 WP_255382292.1 hypothetical protein -
MYG64_RS31225 (MYG64_31105) 738522..739037 + 516 WP_060529874.1 SgcJ/EcaC family oxidoreductase -
MYG64_RS31230 (MYG64_31110) 739030..739503 + 474 WP_255382293.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1586769 1586769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10969.62 Da        Isoelectric Point: 6.9895

>T252194 WP_034798189.1 NZ_CP101519:735209-735502 [Ensifer adhaerens]
MAFRLSVAAEEDIIAIAADGVRLFGSAQARRYHDELFAVFALIAANPRMARERTELSPPMRIHPFKAHLVVYRVEADGDI
LVVRVRHGHEDWISNAF

Download         Length: 294 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9247.39 Da        Isoelectric Point: 8.5610

>AT252194 WP_034798187.1 NZ_CP101519:734961-735209 [Ensifer adhaerens]
MATMNVSLPDPMKDWVEAQTRTGRYANASDYVRDLIRRDQERNDKVAVMQRFVDDGLKSGVGSRSKDELFSAALTRAEVP
RG

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H0CJK8

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0CJP6

References