Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1536970..1537676 Replicon plasmid pA
Accession NZ_CP101518
Organism Ensifer adhaerens strain NER9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MYG64_RS26835 Protein ID WP_255381094.1
Coordinates 1537233..1537676 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H0BN26
Locus tag MYG64_RS26830 Protein ID WP_034800189.1
Coordinates 1536970..1537236 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG64_RS26810 (MYG64_26720) 1533308..1534357 + 1050 WP_060529687.1 ABC transporter permease -
MYG64_RS26815 (MYG64_26725) 1534359..1535300 + 942 WP_034800188.1 ABC transporter permease -
MYG64_RS26820 (MYG64_26730) 1535297..1536589 + 1293 WP_255381093.1 amidohydrolase family protein -
MYG64_RS26825 (MYG64_26735) 1536637..1536791 - 155 Protein_1389 transcriptional regulator -
MYG64_RS26830 (MYG64_26740) 1536970..1537236 + 267 WP_034800189.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MYG64_RS26835 (MYG64_26745) 1537233..1537676 + 444 WP_255381094.1 type II toxin-antitoxin system VapC family toxin Toxin
MYG64_RS26840 (MYG64_26750) 1537946..1538194 + 249 WP_034800193.1 hypothetical protein -
MYG64_RS26845 (MYG64_26755) 1538413..1539453 + 1041 WP_192441859.1 ABC transporter substrate-binding protein -
MYG64_RS26850 (MYG64_26760) 1539579..1540343 + 765 WP_060529703.1 ABC transporter permease -
MYG64_RS26855 (MYG64_26765) 1540359..1541162 + 804 WP_255381096.1 ABC transporter permease -
MYG64_RS26860 (MYG64_26770) 1541159..1542247 + 1089 WP_034800202.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA 1..1781172 1781172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15655.14 Da        Isoelectric Point: 6.9294

>T252190 WP_255381094.1 NZ_CP101518:1537233-1537676 [Ensifer adhaerens]
VSNLFMLDTNIVSELARNPRGQVAERIAAVGSEAICVSIITAAELRYGCAKKGSPKLLAQIEALLESILVLALDVPADAK
YGNIRTELEAAGKPIGPNDLLIAAHACAAGAVLVTANAREFTRIPNLRVENWLDATSKQLRVPPTER

Download         Length: 444 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.58 Da        Isoelectric Point: 4.8781

>AT252190 WP_034800189.1 NZ_CP101518:1536970-1537236 [Ensifer adhaerens]
MPQIRHNEPPAREAKLFRNNKSQAVRIPADFELPGDRVMIHRDGDRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDIDETL
LPAKEIDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0BN26

References