Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 822578..823458 Replicon plasmid pA
Accession NZ_CP101518
Organism Ensifer adhaerens strain NER9

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MYG64_RS23540 Protein ID WP_192443344.1
Coordinates 822949..823458 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1G9YN41
Locus tag MYG64_RS23535 Protein ID WP_060529162.1
Coordinates 822578..822949 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG64_RS23515 (MYG64_23440) 818471..818854 + 384 WP_060529107.1 RidA family protein -
MYG64_RS23520 (MYG64_23445) 818870..820858 + 1989 WP_162765831.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
MYG64_RS23525 (MYG64_23450) 820855..821724 + 870 WP_113504331.1 hydroxymethylglutaryl-CoA lyase -
MYG64_RS23530 (MYG64_23455) 821721..822506 + 786 WP_192443345.1 crotonase/enoyl-CoA hydratase family protein -
MYG64_RS23535 (MYG64_23460) 822578..822949 + 372 WP_060529162.1 DUF2384 domain-containing protein Antitoxin
MYG64_RS23540 (MYG64_23465) 822949..823458 + 510 WP_192443344.1 RES domain-containing protein Toxin
MYG64_RS23545 (MYG64_23470) 823491..824855 - 1365 WP_255381253.1 FAD-binding oxidoreductase -
MYG64_RS23550 (MYG64_23475) 825019..826143 - 1125 WP_064817026.1 sulfate/molybdate ABC transporter ATP-binding protein -
MYG64_RS23555 (MYG64_23480) 826175..827095 - 921 WP_255381254.1 sulfate ABC transporter permease subunit CysW -
MYG64_RS23560 (MYG64_23485) 827085..827951 - 867 WP_082936543.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA 1..1781172 1781172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(8-162)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18741.32 Da        Isoelectric Point: 6.3310

>T252189 WP_192443344.1 NZ_CP101518:822949-823458 [Ensifer adhaerens]
MAVGAPVRLWRAYVPRWAHAPLSGEGAGRYGGRWNPVGTPTIYAARELSTAWAEYNQGFVQHPALIAQLELRFARLADLT
APEILSDLGLTEEIHRCEWRDALDRGLVPETHRLQLALSDRGFDGLIYPSFMSPGGTCVALWHWNAGEGSELKIIDPEGR
LPKTPASWL

Download         Length: 510 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 12900.86 Da        Isoelectric Point: 9.8060

>AT252189 WP_060529162.1 NZ_CP101518:822578-822949 [Ensifer adhaerens]
MAAVGLNISTAHYGESHSSFLSARLVADRLGVTLAELAKLIGVARNTLTAKSSARKVDAALSSVVRILAMAGEMAGDDSR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1G9YN41

References