Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 17408..18048 Replicon plasmid pA
Accession NZ_CP101518
Organism Ensifer adhaerens strain NER9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MYG64_RS19950 Protein ID WP_060530470.1
Coordinates 17408..17815 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MYG64_RS19955 Protein ID WP_034805861.1
Coordinates 17815..18048 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG64_RS19930 (MYG64_19875) 13673..14587 + 915 WP_034805874.1 LysR substrate-binding domain-containing protein -
MYG64_RS19935 (MYG64_19880) 14673..15215 + 543 WP_255381133.1 GNAT family protein -
MYG64_RS19940 (MYG64_19885) 15209..16381 - 1173 WP_060522056.1 4-hydroxybenzoate 3-monooxygenase -
MYG64_RS19945 (MYG64_19890) 16510..17397 + 888 WP_255381134.1 helix-turn-helix domain-containing protein -
MYG64_RS19950 (MYG64_19895) 17408..17815 - 408 WP_060530470.1 tRNA(fMet)-specific endonuclease VapC Toxin
MYG64_RS19955 (MYG64_19900) 17815..18048 - 234 WP_034805861.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MYG64_RS19960 (MYG64_19905) 18286..19734 + 1449 WP_060530469.1 NCS1 family nucleobase:cation symporter-1 -
MYG64_RS19965 (MYG64_19910) 19782..20720 - 939 WP_060530468.1 sterol desaturase family protein -
MYG64_RS19970 (MYG64_19915) 20720..21163 - 444 WP_060530467.1 hypothetical protein -
MYG64_RS19975 (MYG64_19920) 21195..22664 + 1470 WP_255381135.1 amidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA 1..1781172 1781172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(9-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15138.25 Da        Isoelectric Point: 7.9025

>T252188 WP_060530470.1 NZ_CP101518:c17815-17408 [Ensifer adhaerens]
MLKYMLDTNICIYTVKNRPQQVREAFNRHHGQLCISSVSLMELIYGAERSAMPERNLSVIEGFAARLEVLNYDQAAASHT
GQLRAELARSGTPIGPYDQLIAGHARSQGLILVTNNRREFDRVPGLRVEDWTAAP

Download         Length: 408 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8665.81 Da        Isoelectric Point: 4.4013

>AT252188 WP_034805861.1 NZ_CP101518:c18048-17815 [Ensifer adhaerens]
MSEQGAVFLTNRSQAIRLPRAVALPEDVKRVDIVAVGRTRIITPAGEAWDSWFDGELVTADFMVQREQPEAQEREPL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References