Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2441098..2441734 Replicon chromosome
Accession NZ_CP101399
Organism Bacillus altitudinis strain HM-7

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag NM232_RS12835 Protein ID WP_003214169.1
Coordinates 2441384..2441734 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag NM232_RS12830 Protein ID WP_003214273.1
Coordinates 2441098..2441379 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM232_RS12810 2437252..2437857 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
NM232_RS12815 2437952..2438317 + 366 WP_048001253.1 holo-ACP synthase -
NM232_RS12820 2438478..2439494 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
NM232_RS12825 2439623..2440804 + 1182 WP_255233610.1 alanine racemase -
NM232_RS12830 2441098..2441379 + 282 WP_003214273.1 hypothetical protein Antitoxin
NM232_RS12835 2441384..2441734 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NM232_RS12840 2441849..2442679 + 831 WP_007496484.1 RsbT co-antagonist protein RsbRA -
NM232_RS12845 2442684..2443052 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
NM232_RS12850 2443055..2443456 + 402 WP_003214085.1 anti-sigma regulatory factor -
NM232_RS12855 2443467..2444474 + 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
NM232_RS12860 2444534..2444863 + 330 WP_024425392.1 anti-sigma factor antagonist -
NM232_RS12865 2444860..2445348 + 489 WP_178929502.1 anti-sigma B factor RsbW -
NM232_RS12870 2445314..2446102 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
NM232_RS12875 2446102..2446701 + 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T252134 WP_003214169.1 NZ_CP101399:2441384-2441734 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT252134 WP_003214273.1 NZ_CP101399:2441098-2441379 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References