Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2752026..2752664 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NMK57_RS13725 Protein ID WP_000813794.1
Coordinates 2752488..2752664 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NMK57_RS13720 Protein ID WP_001270286.1
Coordinates 2752026..2752442 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS13700 (2747178) 2747178..2748119 - 942 WP_001251313.1 ABC transporter permease -
NMK57_RS13705 (2748120) 2748120..2749133 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NMK57_RS13710 (2749151) 2749151..2750296 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NMK57_RS13715 (2750541) 2750541..2751947 - 1407 WP_000760614.1 PLP-dependent aminotransferase family protein -
NMK57_RS13720 (2752026) 2752026..2752442 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NMK57_RS13725 (2752488) 2752488..2752664 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NMK57_RS13730 (2752886) 2752886..2753116 + 231 WP_000494244.1 YncJ family protein -
NMK57_RS13735 (2753208) 2753208..2755169 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NMK57_RS13740 (2755242) 2755242..2755778 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
NMK57_RS13745 (2755870) 2755870..2757045 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T251869 WP_000813794.1 NZ_CP101305:c2752664-2752488 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT251869 WP_001270286.1 NZ_CP101305:c2752442-2752026 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References