Detailed information of TA system TA025186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2389466..2390034
• Replicon: chromosome
• Accession: NC_015385
• Organism: Treponema succinifaciens DSM 2489

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F2NTN8
• Locus tag: TRESU_RS11330
• Protein ID: WP_013702349.1
• Coordinates: 2389735..2390034 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F2NTN7
• Locus tag: TRESU_RS11325
• Protein ID: WP_013702348.1
• Coordinates: 2389466..2389738 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TRESU_RS11300	2384984..2385469	-	486	WP_013702343.1	S-ribosylhomocysteine lyase	-
TRESU_RS11305	2385493..2386146	-	654	WP_013702344.1	HAD hydrolase-like protein	-
TRESU_RS11310	2386146..2387480	-	1335	WP_081454789.1	aminopeptidase	-
TRESU_RS11315	2387621..2388241	+	621	WP_013702346.1	CarD family transcriptional regulator	-
TRESU_RS11320	2388231..2389415	+	1185	WP_052299605.1	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
TRESU_RS11325	2389466..2389738	+	273	WP_013702348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TRESU_RS11330	2389735..2390034	+	300	WP_013702349.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TRESU_RS14375	2390087..2390350	-	264	WP_169309767.1	helix-turn-helix transcriptional regulator	-
TRESU_RS11340	2390564..2391049	+	486	WP_013702351.1	hypothetical protein	-
TRESU_RS11345	2391132..2391482	+	351	WP_013702352.1	hypothetical protein	-
TRESU_RS11350	2391537..2392043	+	507	WP_013702353.1	hypothetical protein	-
TRESU_RS14380	2392062..2392739	+	678	WP_013702354.1	hypothetical protein	-
TRESU_RS11360	2392839..2393351	+	513	WP_148228285.1	hypothetical protein	-
TRESU_RS11365	2393393..2394076	+	684	WP_013702356.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-63)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11518.54 Da
• Isoelectric Point: 10.2697

>T25186 WP_013702349.1 NC_015385:2389735-2390034 [Treponema succinifaciens DSM 2489]
MSENFYKYKTRATKRFKKHAKLVKKRSVKDSEKLKSAVELLAKGEKLPERFRDHELAGNLKGSRECHILLDLLLIYRIFN
DILILELVDTGSHADLFGM

Nucleotide

• Length: 300 bp

>T25186 NC_015385:2389735-2390034 [Treponema succinifaciens DSM 2489]
ATGAGCGAAAATTTCTACAAATATAAAACCAGAGCAACAAAGCGGTTCAAGAAACATGCGAAACTTGTAAAAAAGCGCAG
CGTGAAAGATTCAGAAAAGCTGAAATCCGCAGTTGAACTTCTTGCAAAAGGCGAAAAACTTCCCGAACGATTCCGCGACC
ACGAGCTTGCAGGAAATCTTAAAGGCAGCCGCGAGTGCCATATTCTGCTGGATTTGCTTTTGATTTACAGGATTTTCAAC
GACATTCTGATTCTTGAGCTTGTTGACACCGGCAGCCATGCGGATTTGTTCGGAATGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10326.63 Da
• Isoelectric Point: 4.4944

>AT25186 WP_013702348.1 NC_015385:2389466-2389738 [Treponema succinifaciens DSM 2489]
MNTVAMNIRVDKNLKEQATELYNDLGLSLSSAINMFLRQSVRENGLPFKPQRTRRKSEIELASEEADQLMNDPNAKTYEA
PQELWDEIGL

Nucleotide

• Length: 273 bp

>AT25186 NC_015385:2389466-2389738 [Treponema succinifaciens DSM 2489]
ATGAACACAGTAGCAATGAATATTAGAGTTGACAAAAATCTCAAGGAACAGGCGACGGAGCTTTACAATGATTTGGGGCT
TTCGCTTTCGAGCGCAATCAATATGTTTTTGCGGCAGTCTGTGAGGGAAAATGGATTGCCGTTCAAGCCGCAGCGGACGA
GGCGAAAGAGCGAGATTGAGCTTGCATCTGAGGAAGCCGACCAGCTTATGAACGACCCGAATGCGAAAACTTACGAGGCT
CCGCAGGAACTTTGGGATGAAATCGGTTTATGA

Structures

Toxin

• AlphaFold DB: F2NTN8

Antitoxin

• AlphaFold DB: F2NTN7