Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 721924..722761 Replicon chromosome
Accession NZ_CP101305
Organism Escherichia coli strain 2002-3211

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9LL67
Locus tag NMK57_RS03535 Protein ID WP_000854687.1
Coordinates 722381..722761 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LJJ3
Locus tag NMK57_RS03530 Protein ID WP_001443392.1
Coordinates 721924..722292 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK57_RS03495 (717030) 717030..717410 + 381 Protein_686 DUF945 domain-containing protein -
NMK57_RS03500 (717923) 717923..719701 + 1779 WP_001243192.1 reverse transcriptase/maturase family protein -
NMK57_RS03505 (719820) 719820..720260 + 441 Protein_688 DUF945 domain-containing protein -
NMK57_RS03510 (720260) 720260..720505 + 246 WP_001164974.1 hypothetical protein -
NMK57_RS03515 (720599) 720599..721072 + 474 WP_000855068.1 antirestriction protein -
NMK57_RS03520 (721088) 721088..721564 + 477 WP_001186728.1 RadC family protein -
NMK57_RS03525 (721627) 721627..721848 + 222 WP_000692312.1 DUF987 domain-containing protein -
NMK57_RS03530 (721924) 721924..722292 + 369 WP_001443392.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NMK57_RS03535 (722381) 722381..722761 + 381 WP_000854687.1 TA system toxin CbtA family protein Toxin
NMK57_RS03540 (722758) 722758..723246 + 489 WP_001054228.1 DUF5983 family protein -
NMK57_RS03545 (723266) 723266..723463 + 198 WP_000772026.1 DUF957 domain-containing protein -
NMK57_RS03550 (723548) 723548..724393 + 846 WP_001274557.1 DUF4942 domain-containing protein -
NMK57_RS03560 (724693) 724693..725199 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
NMK57_RS03565 (725278) 725278..727119 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14199.13 Da        Isoelectric Point: 6.8615

>T251857 WP_000854687.1 NZ_CP101305:722381-722761 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNNITLGRHPEEAKQ

Download         Length: 381 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13781.54 Da        Isoelectric Point: 6.2049

>AT251857 WP_001443392.1 NZ_CP101305:721924-722292 [Escherichia coli]
VSDTLHETNYPNDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLDDRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVALYAKGLTCDADTLGSCGYVYLAVYPTPDMKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LL67

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LJJ3

References