Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1317969..1318594 Replicon chromosome
Accession NZ_CP101245
Organism Escherichia coli strain EC21Z-097

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NML22_RS06395 Protein ID WP_000911330.1
Coordinates 1318196..1318594 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NML22_RS06390 Protein ID WP_000450524.1
Coordinates 1317969..1318196 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML22_RS06365 (1313772) 1313772..1314242 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NML22_RS06370 (1314242) 1314242..1314814 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NML22_RS06375 (1314960) 1314960..1315838 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NML22_RS06380 (1315855) 1315855..1316889 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NML22_RS06385 (1317102) 1317102..1317815 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NML22_RS06390 (1317969) 1317969..1318196 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NML22_RS06395 (1318196) 1318196..1318594 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NML22_RS06400 (1318741) 1318741..1319604 + 864 WP_001267507.1 neutral zinc metallopeptidase -
NML22_RS06405 (1319619) 1319619..1321634 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
NML22_RS06410 (1321708) 1321708..1322406 + 699 WP_000679823.1 esterase -
NML22_RS06415 (1322516) 1322516..1322716 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T251627 WP_000911330.1 NZ_CP101245:1318196-1318594 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT251627 WP_000450524.1 NZ_CP101245:1317969-1318196 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References