Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 72696..73321 Replicon plasmid pEC21Z147-128K
Accession NZ_CP101212
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NML26_RS26450 Protein ID WP_000911313.1
Coordinates 72923..73321 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NML26_RS26445 Protein ID WP_000450520.1
Coordinates 72696..72923 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS26445 (72696) 72696..72923 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
NML26_RS26450 (72923) 72923..73321 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
NML26_RS26455 (73330) 73330..75483 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
NML26_RS26460 (75736) 75736..76446 - 711 WP_230133085.1 conjugal transfer complement resistance protein TraT -
NML26_RS26465 (76499) 76499..76996 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA5 / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..127578 127578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T251535 WP_000911313.1 NZ_CP101212:72923-73321 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT251535 WP_000450520.1 NZ_CP101212:72696-72923 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References