Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1017079..1017733 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NML26_RS05010 Protein ID WP_000244781.1
Coordinates 1017326..1017733 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NML26_RS05005 Protein ID WP_000354046.1
Coordinates 1017079..1017345 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS04985 (1013157) 1013157..1014590 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
NML26_RS04990 (1014635) 1014635..1014946 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
NML26_RS04995 (1015110) 1015110..1015769 + 660 WP_000250269.1 hemolysin III family protein -
NML26_RS05000 (1015846) 1015846..1016826 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
NML26_RS05005 (1017079) 1017079..1017345 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NML26_RS05010 (1017326) 1017326..1017733 + 408 WP_000244781.1 protein YgfX Toxin
NML26_RS05015 (1017773) 1017773..1018294 - 522 WP_001055874.1 flavodoxin FldB -
NML26_RS05020 (1018406) 1018406..1019302 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NML26_RS05025 (1019327) 1019327..1020037 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NML26_RS05030 (1020043) 1020043..1021776 + 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T251511 WP_000244781.1 NZ_CP101210:1017326-1017733 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT251511 WP_000354046.1 NZ_CP101210:1017079-1017345 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References