Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3623800..3624420 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL732_RS17845 Protein ID WP_001280991.1
Coordinates 3624202..3624420 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL732_RS17840 Protein ID WP_000344807.1
Coordinates 3623800..3624174 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS17830 (3618939) 3618939..3620132 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL732_RS17835 (3620155) 3620155..3623304 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL732_RS17840 (3623800) 3623800..3624174 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL732_RS17845 (3624202) 3624202..3624420 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL732_RS17850 (3624599) 3624599..3625150 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL732_RS17855 (3625268) 3625268..3625738 + 471 WP_000136183.1 YlaC family protein -
NL732_RS17860 (3625794) 3625794..3625934 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL732_RS17865 (3625936) 3625936..3626199 - 264 WP_000801422.1 type B 50S ribosomal protein L31 -
NL732_RS17870 (3626424) 3626424..3627974 + 1551 WP_000213145.1 EAL domain-containing protein -
NL732_RS17880 (3628205) 3628205..3628594 + 390 WP_000961285.1 MGMT family protein -
NL732_RS17885 (3628627) 3628627..3629196 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251202 WP_001280991.1 NZ_CP100718:3624202-3624420 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251202 WP_000344807.1 NZ_CP100718:3623800-3624174 [Salmonella enterica subsp. enterica serovar Weltevreden]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References