Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3663315..3663975 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL709_RS17900 Protein ID WP_000244756.1
Coordinates 3663315..3663728 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL709_RS17905 Protein ID WP_000351186.1
Coordinates 3663709..3663975 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS17880 (3659256) 3659256..3660989 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
NL709_RS17885 (3660995) 3660995..3661708 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL709_RS17890 (3661732) 3661732..3662628 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL709_RS17895 (3662741) 3662741..3663262 + 522 WP_001055885.1 flavodoxin FldB -
NL709_RS17900 (3663315) 3663315..3663728 - 414 WP_000244756.1 protein YgfX Toxin
NL709_RS17905 (3663709) 3663709..3663975 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL709_RS17910 (3664225) 3664225..3665205 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NL709_RS17915 (3665321) 3665321..3665980 - 660 WP_000250289.1 hemolysin III family protein -
NL709_RS17920 (3666144) 3666144..3666455 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL709_RS17925 (3666613) 3666613..3668046 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T250934 WP_000244756.1 NZ_CP100666:c3663728-3663315 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT250934 WP_000351186.1 NZ_CP100666:c3663975-3663709 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References