Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 589125..589924 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag NLZ06_RS02890 Protein ID WP_000347267.1
Coordinates 589125..589589 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NLZ06_RS02895 Protein ID WP_001307405.1
Coordinates 589589..589924 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS02860 (584126) 584126..584560 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NLZ06_RS02865 (584578) 584578..585456 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NLZ06_RS02870 (585446) 585446..586225 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NLZ06_RS02875 (586236) 586236..586709 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NLZ06_RS02880 (586732) 586732..588012 - 1281 WP_000681936.1 tagatose-bisphosphate aldolase subunit KbaZ -
NLZ06_RS02885 (588261) 588261..589070 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NLZ06_RS02890 (589125) 589125..589589 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NLZ06_RS02895 (589589) 589589..589924 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NLZ06_RS02900 (590073) 590073..591644 - 1572 WP_001273741.1 galactarate dehydratase -
NLZ06_RS02905 (592019) 592019..593353 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NLZ06_RS02910 (593369) 593369..594139 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 589125..600580 11455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T250824 WP_000347267.1 NZ_CP100544:c589589-589125 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT250824 WP_001307405.1 NZ_CP100544:c589924-589589 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References