Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 692259..692952 Replicon chromosome
Accession NZ_CP100525
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NLZ09_RS03405 Protein ID WP_000415584.1
Coordinates 692259..692555 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NLZ09_RS03410 Protein ID WP_000650107.1
Coordinates 692557..692952 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS03370 (687347) 687347..687661 - 315 WP_000958598.1 putative quinol monooxygenase -
NLZ09_RS03375 (687692) 687692..688273 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NLZ09_RS03380 (688592) 688592..688924 + 333 WP_000917684.1 DUF2645 family protein -
NLZ09_RS03385 (688970) 688970..690319 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
NLZ09_RS03390 (690316) 690316..690975 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NLZ09_RS03395 (691127) 691127..691519 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NLZ09_RS03400 (691572) 691572..692054 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NLZ09_RS03405 (692259) 692259..692555 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NLZ09_RS03410 (692557) 692557..692952 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NLZ09_RS03415 (693085) 693085..694692 + 1608 WP_136699267.1 ABC transporter substrate-binding protein -
NLZ09_RS03420 (694830) 694830..697088 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T250755 WP_000415584.1 NZ_CP100525:692259-692555 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT250755 WP_000650107.1 NZ_CP100525:692557-692952 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References