Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2867064..2867589 Replicon chromosome
Accession NZ_CP100443
Organism Streptomyces rimosus subsp. rimosus strain DV3

Toxin (Protein)


Gene name relE Uniprot ID L8EGB8
Locus tag SRIMDV3_RS11795 Protein ID WP_003987428.1
Coordinates 2867326..2867589 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L8ED57
Locus tag SRIMDV3_RS11790 Protein ID WP_003987429.1
Coordinates 2867064..2867333 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIMDV3_RS11765 (SRIMDV3_11825) 2862096..2862818 + 723 WP_030181983.1 PIG-L deacetylase family protein -
SRIMDV3_RS11770 (SRIMDV3_11830) 2862806..2863774 - 969 WP_003982326.1 alpha/beta hydrolase -
SRIMDV3_RS11775 (SRIMDV3_11835) 2863904..2864413 + 510 WP_003982327.1 hypothetical protein -
SRIMDV3_RS11780 (SRIMDV3_11840) 2864454..2865038 + 585 WP_003982328.1 Uma2 family endonuclease -
SRIMDV3_RS11785 (SRIMDV3_11845) 2865080..2866760 - 1681 Protein_2341 IS1182-like element ISSdi1 family transposase -
SRIMDV3_RS11790 (SRIMDV3_11855) 2867064..2867333 + 270 WP_003987429.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SRIMDV3_RS11795 (SRIMDV3_11860) 2867326..2867589 + 264 WP_003987428.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRIMDV3_RS11800 (SRIMDV3_11865) 2867724..2868812 - 1089 WP_003987427.1 redox-regulated ATPase YchF -
SRIMDV3_RS11805 (SRIMDV3_11870) 2869355..2870062 + 708 WP_063604328.1 hypothetical protein -
SRIMDV3_RS11810 (SRIMDV3_11875) 2870028..2870900 - 873 WP_078586864.1 ROK family protein -
SRIMDV3_RS11815 (SRIMDV3_11880) 2870986..2872029 - 1044 WP_078586862.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-56)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.54 Da        Isoelectric Point: 8.5041

>T250564 WP_003987428.1 NZ_CP100443:2867326-2867589 [Streptomyces rimosus subsp. rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10290.73 Da        Isoelectric Point: 4.7473

>AT250564 WP_003987429.1 NZ_CP100443:2867064-2867333 [Streptomyces rimosus subsp. rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8EGB8

Antitoxin

Source ID Structure
AlphaFold DB L8ED57

References