Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 60167..60593 | Replicon | plasmid pRJKP41-1 |
| Accession | NZ_CP100073 | ||
| Organism | Klebsiella pneumoniae strain RJKP41 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | NIL01_RS26435 | Protein ID | WP_001372321.1 |
| Coordinates | 60167..60292 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 60369..60593 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NIL01_RS26400 (55222) | 55222..55449 | - | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
| NIL01_RS26405 (55543) | 55543..56229 | - | 687 | WP_015059009.1 | PAS domain-containing protein | - |
| NIL01_RS26410 (56420) | 56420..56803 | - | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| NIL01_RS26415 (57080) | 57080..57727 | + | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
| NIL01_RS26420 (58024) | 58024..58845 | - | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| NIL01_RS26425 (58956) | 58956..59252 | - | 297 | WP_001272251.1 | hypothetical protein | - |
| NIL01_RS26430 (59552) | 59552..59848 | + | 297 | Protein_71 | hypothetical protein | - |
| NIL01_RS26435 (60167) | 60167..60292 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| NIL01_RS26440 (60234) | 60234..60383 | - | 150 | Protein_73 | plasmid maintenance protein Mok | - |
| - (60369) | 60369..60593 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (60369) | 60369..60593 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (60369) | 60369..60593 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (60369) | 60369..60593 | - | 225 | NuclAT_0 | - | Antitoxin |
| NIL01_RS26445 (60605) | 60605..61324 | - | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| NIL01_RS26450 (61321) | 61321..61755 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| NIL01_RS26455 (61824) | 61824..63847 | - | 2024 | Protein_76 | ParB/RepB/Spo0J family partition protein | - |
| NIL01_RS26460 (63908) | 63908..64141 | - | 234 | WP_000006003.1 | DUF905 family protein | - |
| NIL01_RS26465 (64199) | 64199..64726 | - | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| NIL01_RS26470 (65028) | 65028..65483 | + | 456 | Protein_79 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaKPC-2 / rmtB / blaTEM-1B / fosA3 / blaCTX-M-65 / catA2 | - | 1..164564 | 164564 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T250047 WP_001372321.1 NZ_CP100073:c60292-60167 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
Antitoxin
Download Length: 225 bp
>AT250047 NZ_CP100073:c60593-60369 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
