Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2406269..2406873 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag NIY85_RS11970 Protein ID WP_000638401.1
Coordinates 2406487..2406873 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag NIY85_RS11965 Protein ID WP_001195490.1
Coordinates 2406269..2406490 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS11945 (2402437) 2402437..2403351 + 915 WP_024164792.1 bestrophin family protein -
NIY85_RS11950 (2403355) 2403355..2404113 - 759 WP_025239009.1 trans-aconitate 2-methyltransferase -
NIY85_RS11955 (2404703) 2404703..2405029 + 327 Protein_2343 site-specific integrase -
NIY85_RS11960 (2405026) 2405026..2406069 + 1044 WP_256876820.1 hypothetical protein -
NIY85_RS11965 (2406269) 2406269..2406490 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIY85_RS11970 (2406487) 2406487..2406873 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIY85_RS11975 (2406953) 2406953..2407396 - 444 WP_256878478.1 autotransporter outer membrane beta-barrel domain-containing protein -
NIY85_RS11980 (2407762) 2407762..2409414 - 1653 WP_244251443.1 ESPR-type extended signal peptide-containing protein -
NIY85_RS11985 (2410104) 2410104..2410325 + 222 Protein_2349 sulfatase -
NIY85_RS11990 (2410417) 2410417..2411645 + 1229 WP_112017357.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T249955 WP_000638401.1 NZ_CP099912:2406487-2406873 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT249955 WP_001195490.1 NZ_CP099912:2406269-2406490 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References