Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 7758..8556 Replicon plasmid plas1
Accession NZ_CP099899
Organism Escherichia albertii strain 147_1_TBG_A

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ13_RS23050 Protein ID WP_000072677.1
Coordinates 7758..8279 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ13_RS23055 Protein ID WP_001351987.1
Coordinates 8287..8556 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ13_RS23035 (NIZ13_23020) 6307..6630 + 324 WP_000064175.1 hypothetical protein -
NIZ13_RS23040 (NIZ13_23025) 6644..7336 + 693 WP_012640731.1 hypothetical protein -
NIZ13_RS23045 (NIZ13_23030) 7338..7589 + 252 WP_000901559.1 hypothetical protein -
NIZ13_RS23050 (NIZ13_23035) 7758..8279 - 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ13_RS23055 (NIZ13_23040) 8287..8556 - 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ13_RS23060 (NIZ13_23045) 8875..9543 + 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ13_RS23065 (NIZ13_23050) 9549..9902 + 354 WP_160378290.1 hypothetical protein -
NIZ13_RS23070 (NIZ13_23055) 9955..10722 - 768 WP_000342417.1 hypothetical protein -
NIZ13_RS23075 (NIZ13_23060) 11005..11745 + 741 WP_001717320.1 hypothetical protein -
NIZ13_RS23080 (NIZ13_23065) 12016..13128 + 1113 WP_072108001.1 DnaB-like helicase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..107097 107097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249836 WP_000072677.1 NZ_CP099899:c8279-7758 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249836 WP_001351987.1 NZ_CP099899:c8556-8287 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References