Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4036593..4037393 Replicon chromosome
Accession NZ_CP099883
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NIZ20_RS19695 Protein ID WP_059225129.1
Coordinates 4036593..4037120 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIZ20_RS19700 Protein ID WP_001277106.1
Coordinates 4037127..4037393 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS19670 (4031668) 4031668..4032435 - 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NIZ20_RS19675 (4032432) 4032432..4033709 - 1278 WP_059225128.1 branched chain amino acid ABC transporter permease LivM -
NIZ20_RS19680 (4033706) 4033706..4034632 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ20_RS19685 (4034680) 4034680..4035789 - 1110 Protein_3838 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ20_RS19690 (4036213) 4036213..4036596 + 384 WP_000778776.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ20_RS19695 (4036593) 4036593..4037120 - 528 WP_059225129.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ20_RS19700 (4037127) 4037127..4037393 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ20_RS19705 (4037543) 4037543..4038646 - 1104 WP_072248450.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ20_RS19710 (4038918) 4038918..4039772 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NIZ20_RS19715 (4040017) 4040017..4041075 - 1059 WP_001042000.1 permease-like cell division protein FtsX -
NIZ20_RS19720 (4041068) 4041068..4041736 - 669 WP_000617720.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19690.60 Da        Isoelectric Point: 6.9585

>T249684 WP_059225129.1 NZ_CP099883:c4037120-4036593 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLIAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249684 WP_001277106.1 NZ_CP099883:c4037393-4037127 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References