Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 71647..72248 Replicon plasmid plas2
Accession NZ_CP099870
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NIZ25_RS24485 Protein ID WP_001216045.1
Coordinates 71868..72248 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NIZ25_RS24480 Protein ID WP_001190712.1
Coordinates 71647..71868 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS24470 (NIZ25_24445) 68685..69911 - 1227 WP_256876192.1 restriction endonuclease subunit S -
NIZ25_RS24475 (NIZ25_24450) 69908..71464 - 1557 WP_073511017.1 type I restriction-modification system subunit M -
NIZ25_RS24480 (NIZ25_24455) 71647..71868 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIZ25_RS24485 (NIZ25_24460) 71868..72248 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIZ25_RS24490 (NIZ25_24465) 72253..72432 + 180 WP_000113019.1 hypothetical protein -
NIZ25_RS24495 (NIZ25_24470) 72460..73503 + 1044 WP_256876191.1 DUF968 domain-containing protein -
NIZ25_RS24500 (NIZ25_24475) 73592..74044 + 453 WP_001326849.1 late promoter-activating protein -
NIZ25_RS24505 (NIZ25_24480) 74131..75324 + 1194 WP_000219618.1 hypothetical protein -
NIZ25_RS24510 (NIZ25_24485) 75324..76808 + 1485 WP_000124159.1 hypothetical protein -
NIZ25_RS24515 (NIZ25_24490) 76892..77122 + 231 Protein_79 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..122706 122706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T249564 WP_001216045.1 NZ_CP099870:71868-72248 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT249564 WP_001190712.1 NZ_CP099870:71647-71868 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References