Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 64084..64727 Replicon plasmid plas1
Accession NZ_CP099869
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIZ25_RS23920 Protein ID WP_256876211.1
Coordinates 64311..64727 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIZ25_RS23915 Protein ID WP_256876210.1
Coordinates 64084..64314 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS23890 (60157) 60157..60684 - 528 WP_000203268.1 colicin B immunity protein -
NIZ25_RS23895 (60927) 60927..61742 + 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIZ25_RS23900 (61792) 61792..62145 - 354 WP_000864812.1 colicin M immunity protein -
NIZ25_RS23905 (62318) 62318..63100 - 783 WP_021533580.1 site-specific integrase -
NIZ25_RS23910 (63102) 63102..63515 - 414 WP_000465043.1 hypothetical protein -
NIZ25_RS23915 (64084) 64084..64314 + 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIZ25_RS23920 (64311) 64311..64727 + 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIZ25_RS23925 (64867) 64867..65847 + 981 WP_256876212.1 hypothetical protein -
NIZ25_RS23930 (66055) 66055..67626 - 1572 WP_256876213.1 ATP-binding protein -
NIZ25_RS23935 (67945) 67945..68214 + 270 WP_256876214.1 hypothetical protein -
NIZ25_RS23940 (68202) 68202..68798 + 597 WP_256876215.1 hypothetical protein -
NIZ25_RS23945 (69335) 69335..69676 + 342 Protein_86 protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 1..105541 105541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249563 WP_256876211.1 NZ_CP099869:64311-64727 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249563 WP_256876210.1 NZ_CP099869:64084-64314 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References