Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2476478..2477040 Replicon chromosome
Accession NZ_CP099868
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag NIZ25_RS12140 Protein ID WP_000605676.1
Coordinates 2476478..2476756 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ25_RS12145 Protein ID WP_000781369.1
Coordinates 2476756..2477040 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS12120 (2472468) 2472468..2472899 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIZ25_RS12125 (2473157) 2473157..2473294 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ25_RS12130 (2473451) 2473451..2475148 + 1698 WP_059225292.1 malate dehydrogenase -
NIZ25_RS12135 (2475282) 2475282..2476292 + 1011 WP_059225293.1 alcohol dehydrogenase AdhP -
NIZ25_RS12140 (2476478) 2476478..2476756 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ25_RS12145 (2476756) 2476756..2477040 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIZ25_RS12150 (2477045) 2477045..2477521 - 477 WP_059225294.1 NUDIX domain-containing protein -
NIZ25_RS12155 (2477594) 2477594..2478247 - 654 WP_256876185.1 formate dehydrogenase-N subunit gamma -
NIZ25_RS12160 (2478240) 2478240..2479124 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T249548 WP_000605676.1 NZ_CP099868:2476478-2476756 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249548 WP_000781369.1 NZ_CP099868:2476756-2477040 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References