Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2782080..2782682 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NHF43_RS13365 Protein ID WP_000897305.1
Coordinates 2782371..2782682 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NHF43_RS13360 Protein ID WP_000356397.1
Coordinates 2782080..2782370 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS13335 (2778025) 2778025..2778927 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NHF43_RS13340 (2778924) 2778924..2779559 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NHF43_RS13345 (2779556) 2779556..2780485 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NHF43_RS13350 (2780815) 2780815..2781057 - 243 WP_001087409.1 protein YiiF -
NHF43_RS13355 (2781276) 2781276..2781494 - 219 WP_001295676.1 CopG family transcriptional regulator -
NHF43_RS13360 (2782080) 2782080..2782370 - 291 WP_000356397.1 NadS family protein Antitoxin
NHF43_RS13365 (2782371) 2782371..2782682 - 312 WP_000897305.1 hypothetical protein Toxin
NHF43_RS13370 (2782911) 2782911..2783819 + 909 WP_001162704.1 alpha/beta hydrolase -
NHF43_RS13375 (2783883) 2783883..2784824 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NHF43_RS13380 (2784869) 2784869..2785306 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NHF43_RS13385 (2785303) 2785303..2786175 - 873 WP_000920762.1 virulence factor BrkB family protein -
NHF43_RS13390 (2786169) 2786169..2786768 - 600 WP_001295269.1 glucose-1-phosphatase -
NHF43_RS13395 (2786867) 2786867..2787652 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T249406 WP_000897305.1 NZ_CP099752:c2782682-2782371 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT249406 WP_000356397.1 NZ_CP099752:c2782370-2782080 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References