Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4759795..4760311 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag NHF44_RS23045 Protein ID WP_004894697.1
Coordinates 4759795..4760079 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NHF44_RS23050 Protein ID WP_002886901.1
Coordinates 4760069..4760311 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS23020 (NHF44_23005) 4755190..4755453 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
NHF44_RS23025 (NHF44_23010) 4755583..4755756 + 174 WP_002886906.1 hypothetical protein -
NHF44_RS23030 (NHF44_23015) 4755759..4756502 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
NHF44_RS23035 (NHF44_23020) 4756860..4758998 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
NHF44_RS23040 (NHF44_23025) 4759327..4759791 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NHF44_RS23045 (NHF44_23030) 4759795..4760079 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHF44_RS23050 (NHF44_23035) 4760069..4760311 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NHF44_RS23055 (NHF44_23040) 4760389..4762299 - 1911 WP_023325426.1 PRD domain-containing protein -
NHF44_RS23060 (NHF44_23045) 4762322..4763476 - 1155 WP_004178372.1 lactonase family protein -
NHF44_RS23065 (NHF44_23050) 4763543..4764283 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T249369 WP_004894697.1 NZ_CP099743:c4760079-4759795 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT249369 WP_002886901.1 NZ_CP099743:c4760311-4760069 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References