Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1858833..1860626 Replicon chromosome
Accession NZ_CP099625
Organism Paraburkholderia fungorum strain OTU2BAGNBA1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NFE55_RS31185 Protein ID WP_252889489.1
Coordinates 1859727..1860626 (-) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NFE55_RS31180 Protein ID WP_252889488.1
Coordinates 1858833..1859726 (-) Length 298 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFE55_RS31160 (NFE55_31165) 1854030..1855520 - 1491 WP_046572111.1 aldehyde dehydrogenase -
NFE55_RS31165 (NFE55_31170) 1855553..1856383 - 831 WP_106356175.1 aspartate dehydrogenase -
NFE55_RS31170 (NFE55_31175) 1856376..1858034 - 1659 WP_106356173.1 thiamine pyrophosphate-binding protein -
NFE55_RS31175 (NFE55_31180) 1858027..1858836 - 810 WP_252889487.1 SDR family oxidoreductase -
NFE55_RS31180 (NFE55_31185) 1858833..1859726 - 894 WP_252889488.1 IclR family transcriptional regulator Antitoxin
NFE55_RS31185 (NFE55_31190) 1859727..1860626 - 900 WP_252889489.1 alpha/beta hydrolase Toxin
NFE55_RS31190 (NFE55_31195) 1860661..1861188 - 528 WP_216750882.1 cupin domain-containing protein -
NFE55_RS31195 (NFE55_31200) 1861215..1861991 - 777 WP_252889490.1 SDR family oxidoreductase -
NFE55_RS31200 (NFE55_31205) 1861984..1863081 - 1098 WP_030103724.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NFE55_RS31205 (NFE55_31210) 1863131..1863442 - 312 WP_030103723.1 hypothetical protein -
NFE55_RS31210 (NFE55_31215) 1863444..1863758 - 315 WP_028195935.1 non-heme iron oxygenase ferredoxin subunit -
NFE55_RS31215 (NFE55_31220) 1864200..1865276 + 1077 WP_030103722.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-282)

Antitoxin

Transcription regulator IclR, N-terminal

(32-80)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31516.63 Da        Isoelectric Point: 5.6619

>T249272 WP_252889489.1 NZ_CP099625:c1860626-1859727 [Paraburkholderia fungorum]
MSAVPSRIADNVDQNATLEARLARFPAQQIWLASQRAVSYREADSAASDALPLVLLHGIGSGAASWVQQFEVLGETRCVL
AWDAPGYGASTPVEADSPAAGDYATVLKEWLDALGIERCVLLGHSLGAIVAGAFAVTNPQLVAGLLLLSPAGGYGASPAD
VRESKRNQRLAMIKELGPQGLAEKRSTNMLSANASDEARAWVRWNMSRVIPRGYVQATHLLANADLASDLARYKGHISIA
VGADDAITPPEACERLALTASTRLQVVPGAGHAGYIEAPTAYTAIIDTFCRASDGQRSQ

Download         Length: 900 bp

Antitoxin


Download         Length: 298 a.a.        Molecular weight: 33002.57 Da        Isoelectric Point: 6.2995

>AT249272 WP_252889488.1 NZ_CP099625:c1859726-1858833 [Paraburkholderia fungorum]
MTPDTINAERDADDDRNDADASSEINYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLP
AYATTHGQVLMSDMTLDELKKLYPEPELERFTKQTPATVEELYERVCDDARRGYAISESSFERGISVVSAPVRNDTGRIV
AVITTTIPRPEIDASLLDSGLIDKVRRAADELSQRLNYRPKGSANAGTKYMKALGLK

Download         Length: 894 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References