Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 873863..874452 Replicon chromosome
Accession NZ_CP099601
Organism Pseudomonas siliginis strain OTU6MONEA1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NF679_RS03700 Protein ID WP_252868787.1
Coordinates 874201..874452 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NF679_RS03695 Protein ID WP_056782875.1
Coordinates 873863..874204 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF679_RS03670 (NF679_03670) 869534..869935 + 402 WP_016771753.1 30S ribosome-binding factor RbfA -
NF679_RS03675 (NF679_03675) 869940..870857 + 918 WP_150636060.1 tRNA pseudouridine(55) synthase TruB -
NF679_RS03680 (NF679_03680) 871001..871270 + 270 WP_016771751.1 30S ribosomal protein S15 -
NF679_RS03685 (NF679_03685) 871475..873580 + 2106 WP_024011572.1 polyribonucleotide nucleotidyltransferase -
NF679_RS03695 (NF679_03695) 873863..874204 - 342 WP_056782875.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NF679_RS03700 (NF679_03700) 874201..874452 - 252 WP_252868787.1 type II toxin-antitoxin system HicA family toxin Toxin
NF679_RS03705 (NF679_03705) 874807..875106 + 300 WP_041477935.1 DUF6388 family protein -
NF679_RS03710 (NF679_03710) 875231..876079 - 849 WP_016771747.1 carboxylating nicotinate-nucleotide diphosphorylase -
NF679_RS03715 (NF679_03715) 876344..878521 + 2178 WP_236169290.1 DUF1631 domain-containing protein -
NF679_RS03720 (NF679_03720) 878586..879146 + 561 WP_122747368.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9136.55 Da        Isoelectric Point: 10.5416

>T249224 WP_252868787.1 NZ_CP099601:c874452-874201 [Pseudomonas siliginis]
MSKTEKLLAKLANGQSAFTWSELVTLLARLGYSQLEGSGSRIKFDNGNPSAMINLHKPHPGNEIKTYARRQIIEQLKTGG
LIP

Download         Length: 252 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12593.23 Da        Isoelectric Point: 6.3189

>AT249224 WP_056782875.1 NZ_CP099601:c874204-873863 [Pseudomonas siliginis]
MSSQLHYKGYVGSIEASTEDKCLFGKLLFIRALVNYEGQTVAELEAAFREAVDDYLQTCQQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References