Detailed information of TA system TA248983

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2784834..2785413
• Replicon: chromosome
• Accession: NZ_CP099499
• Organism: Staphylococcus aureus strain 0610-H-2A

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LPT19_RS13555
• Protein ID: WP_001025401.1
• Coordinates: 2784834..2785079 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2785048..2785413 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPT19_RS13510 (LPT19_13510)	2780990..2781340	+	351	WP_223200492.1	hypothetical protein	-
LPT19_RS13515 (LPT19_13515)	2781538..2781933	-	396	WP_000449655.1	hypothetical protein	-
LPT19_RS13520 (LPT19_13520)	2781962..2782396	-	435	WP_000755721.1	hypothetical protein	-
LPT19_RS13525 (LPT19_13525)	2782414..2782872	-	459	WP_113532524.1	toxin	-
LPT19_RS13530 (LPT19_13530)	2782894..2783220	-	327	WP_000455972.1	helix-turn-helix transcriptional regulator	-
LPT19_RS13535 (LPT19_13535)	2783383..2783592	+	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
LPT19_RS13540 (LPT19_13540)	2783631..2784407	+	777	WP_031914835.1	Rha family transcriptional regulator	-
LPT19_RS13545 (LPT19_13545)	2784436..2784579	+	144	WP_000939498.1	hypothetical protein	-
LPT19_RS13550 (LPT19_13550)	2784569..2784778	-	210	WP_000642492.1	hypothetical protein	-
LPT19_RS13555 (LPT19_13555)	2784834..2785079	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LPT19_RS13560 (LPT19_13560)	2785048..2785413	-	366	WP_001128433.1	hypothetical protein	Antitoxin
LPT19_RS13565 (LPT19_13565)	2785468..2785683	+	216	WP_001097552.1	hypothetical protein	-
LPT19_RS13570 (LPT19_13570)	2785708..2785971	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
LPT19_RS13575 (LPT19_13575)	2785984..2786145	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
LPT19_RS13580 (LPT19_13580)	2786224..2786547	+	324	WP_000174994.1	hypothetical protein	-
LPT19_RS13585 (LPT19_13585)	2786562..2786924	+	363	WP_031775157.1	hypothetical protein	-
LPT19_RS13590 (LPT19_13590)	2786921..2788087	+	1167	WP_031883894.1	DUF2800 domain-containing protein	-
LPT19_RS13595 (LPT19_13595)	2788114..2788668	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2779402..2801808	22406
	-	inside	Prophage	-	geh	2774846..2801808	26962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T248983 WP_001025401.1 NZ_CP099499:2784834-2785079 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT248983 NZ_CP099499:c2785413-2785048 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin