Detailed information of TA system TA024893

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 717574..718252
• Replicon: chromosome
• Accession: NC_014500
• Organism: Dickeya dadantii 3937

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: E0SLQ1
• Locus tag: DDA3937_RS03285
• Protein ID: WP_013316362.1
• Coordinates: 717821..718252 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: DDA3937_RS03280
• Protein ID: WP_013316361.1
• Coordinates: 717574..717840 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDA3937_RS03260 (Dda3937_02305)	714020..714673	+	654	WP_202796563.1	LysE family translocator	-
DDA3937_RS03265 (Dda3937_02304)	714743..715351	-	609	WP_013316358.1	HD domain-containing protein	-
DDA3937_RS03270 (Dda3937_02303)	715560..716210	+	651	WP_013316359.1	hemolysin III family protein	-
DDA3937_RS03275 (Dda3937_02302)	716283..717263	-	981	WP_013316360.1	tRNA-modifying protein YgfZ	-
DDA3937_RS03280 (Dda3937_02301)	717574..717840	+	267	WP_013316361.1	FAD assembly factor SdhE	Antitoxin
DDA3937_RS03285 (Dda3937_02300)	717821..718252	+	432	WP_013316362.1	protein YgfX	Toxin
DDA3937_RS03290 (Dda3937_02299)	718349..718867	-	519	WP_013316363.1	flavodoxin FldB	-
DDA3937_RS03295 (Dda3937_02298)	718996..720321	-	1326	WP_013316364.1	MHS family MFS transporter	-
DDA3937_RS03300 (Dda3937_02296)	720584..721483	+	900	WP_013316366.1	site-specific tyrosine recombinase XerD	-
DDA3937_RS03305 (Dda3937_02295)	721572..722288	+	717	WP_013316367.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16838.53 Da
• Isoelectric Point: 10.7687

>T24893 WP_013316362.1 NC_014500:717821-718252 [Dickeya dadantii 3937]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVFSQRIIKTRQGEISLHGENQLHWQQR
DWQIVRRPWLMRNGVLLSLRAVDGKGHQRLWLASDSMGNEEWRLLRQLLQQHSLQGTESSHHH

Nucleotide

• Length: 432 bp

>T24893 NC_014500:717821-718252 [Dickeya dadantii 3937]
GTGGCCCAGTGGCAATGTGATTTGCGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGCTGGTGACGCTGGTGGTGTTCGGTTTTG
TGTTCAGCCAGCGCATCATCAAGACGCGTCAGGGGGAGATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTCCGGCGGCCGTGGCTGATGCGCAACGGCGTGTTGCTGTCATTGCGGGCGGTGGATGGCAAAGGGCA
TCAACGCCTGTGGCTGGCGTCTGACAGTATGGGCAACGAAGAGTGGCGGCTGTTGCGCCAACTGCTGCAGCAGCATTCGC
TGCAGGGAACGGAATCCTCCCACCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10476.98 Da
• Isoelectric Point: 5.5981

>AT24893 WP_013316361.1 NC_014500:717574-717840 [Dickeya dadantii 3937]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT24893 NC_014500:717574-717840 [Dickeya dadantii 3937]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAGCTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCAGTTCATCCGTCTGTTACAGTGCGACGATCCCGACT
TGTTCAACTGGTTGATGAACCACGGCGAGCCGGTGGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: E0SLQ1