Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3674909..3675529 Replicon chromosome
Accession NZ_CP099387
Organism Citrobacter braakii strain RHB08-E3-C01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ49_RS17810 Protein ID WP_002892050.1
Coordinates 3675311..3675529 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFJ49_RS17805 Protein ID WP_003021733.1
Coordinates 3674909..3675283 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ49_RS17795 (3670056) 3670056..3671249 + 1194 WP_053389373.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ49_RS17800 (3671272) 3671272..3674421 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ49_RS17805 (3674909) 3674909..3675283 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFJ49_RS17810 (3675311) 3675311..3675529 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ49_RS17815 (3675710) 3675710..3676261 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ49_RS17820 (3676378) 3676378..3676848 + 471 WP_016152071.1 YlaC family protein -
NFJ49_RS17825 (3676927) 3676927..3677067 - 141 WP_279273108.1 type B 50S ribosomal protein L36 -
NFJ49_RS17830 (3677069) 3677069..3677329 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ49_RS17835 (3677518) 3677518..3679071 + 1554 WP_279273109.1 EAL domain-containing protein -
NFJ49_RS17840 (3679123) 3679123..3679476 - 354 WP_080858962.1 DUF1428 family protein -
NFJ49_RS17845 (3679541) 3679541..3680170 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248830 WP_002892050.1 NZ_CP099387:3675311-3675529 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248830 WP_003021733.1 NZ_CP099387:3674909-3675283 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References