Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2980136..2980726 Replicon chromosome
Accession NZ_CP099387
Organism Citrobacter braakii strain RHB08-E3-C01

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NFJ49_RS14535 Protein ID WP_049041157.1
Coordinates 2980136..2980468 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NFJ49_RS14540 Protein ID WP_049041154.1
Coordinates 2980469..2980726 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ49_RS14510 (2975173) 2975173..2975532 - 360 WP_016156204.1 purine nucleoside phosphoramidase -
NFJ49_RS14515 (2975881) 2975881..2978067 + 2187 WP_275262164.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
NFJ49_RS14525 (2978401) 2978401..2979888 + 1488 WP_049040618.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
NFJ49_RS14535 (2980136) 2980136..2980468 - 333 WP_049041157.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NFJ49_RS14540 (2980469) 2980469..2980726 - 258 WP_049041154.1 antitoxin Antitoxin
NFJ49_RS14545 (2981074) 2981074..2981280 - 207 WP_279272995.1 helix-turn-helix transcriptional regulator -
NFJ49_RS14550 (2981277) 2981277..2981744 - 468 WP_279272996.1 hypothetical protein -
NFJ49_RS14555 (2982237) 2982237..2982776 + 540 WP_279272997.1 AAA family ATPase -
NFJ49_RS14560 (2982805) 2982805..2984442 + 1638 Protein_2859 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11731.54 Da        Isoelectric Point: 8.5572

>T248829 WP_049041157.1 NZ_CP099387:c2980468-2980136 [Citrobacter braakii]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGVGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9370.85 Da        Isoelectric Point: 4.4354

>AT248829 WP_049041154.1 NZ_CP099387:c2980726-2980469 [Citrobacter braakii]
MYTTRLKKVGGSIMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References