Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3267531..3268150 Replicon chromosome
Accession NZ_CP099331
Organism Escherichia fergusonii strain RHB44-C03

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFK96_RS15720 Protein ID WP_001280991.1
Coordinates 3267932..3268150 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NFK96_RS15715 Protein ID WP_104917851.1
Coordinates 3267531..3267905 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK96_RS15705 (3262663) 3262663..3263856 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK96_RS15710 (3263879) 3263879..3267028 + 3150 WP_223684912.1 efflux RND transporter permease AcrB -
NFK96_RS15715 (3267531) 3267531..3267905 + 375 WP_104917851.1 Hha toxicity modulator TomB Antitoxin
NFK96_RS15720 (3267932) 3267932..3268150 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFK96_RS15725 (3268647) 3268647..3269117 + 471 WP_002431406.1 YlaC family protein -
NFK96_RS15730 (3269256) 3269256..3270806 + 1551 WP_001260376.1 EAL domain-containing protein -
NFK96_RS15735 (3270848) 3270848..3271201 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NFK96_RS15745 (3271580) 3271580..3271891 + 312 WP_000409907.1 MGMT family protein -
NFK96_RS15750 (3271922) 3271922..3272494 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248498 WP_001280991.1 NZ_CP099331:3267932-3268150 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.31 Da        Isoelectric Point: 4.8989

>AT248498 WP_104917851.1 NZ_CP099331:3267531-3267905 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References