Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1088204..1088824 Replicon chromosome
Accession NZ_CP099325
Organism Enterobacter ludwigii strain RHB47-SO-C01

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag NFL61_RS05190 Protein ID WP_014168902.1
Coordinates 1088204..1088422 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag NFL61_RS05195 Protein ID WP_020885187.1
Coordinates 1088450..1088824 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL61_RS05160 (NFL61_05160) 1084215..1084475 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
NFL61_RS05165 (NFL61_05165) 1084478..1084618 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFL61_RS05170 (NFL61_05170) 1084615..1085325 - 711 WP_020885191.1 GNAT family protein -
NFL61_RS05175 (NFL61_05175) 1085426..1086886 + 1461 WP_272755829.1 PLP-dependent aminotransferase family protein -
NFL61_RS05180 (NFL61_05180) 1086858..1087325 - 468 WP_020885189.1 YlaC family protein -
NFL61_RS05185 (NFL61_05185) 1087443..1087994 - 552 WP_020885188.1 maltose O-acetyltransferase -
NFL61_RS05190 (NFL61_05190) 1088204..1088422 - 219 WP_014168902.1 HHA domain-containing protein Toxin
NFL61_RS05195 (NFL61_05195) 1088450..1088824 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
NFL61_RS05200 (NFL61_05200) 1089336..1092482 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit AcrB -
NFL61_RS05205 (NFL61_05205) 1092505..1093698 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T248450 WP_014168902.1 NZ_CP099325:c1088422-1088204 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT248450 WP_020885187.1 NZ_CP099325:c1088824-1088450 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References