Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 279183..279814 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag NFJ87_RS01340 Protein ID WP_003837806.1
Coordinates 279183..279458 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag NFJ87_RS01345 Protein ID WP_003837808.1
Coordinates 279455..279814 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS01330 (275234) 275234..277981 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
NFJ87_RS01335 (277981) 277981..279105 + 1125 WP_003837801.1 ABC transporter permease -
NFJ87_RS01340 (279183) 279183..279458 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ87_RS01345 (279455) 279455..279814 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ87_RS01350 (279925) 279925..280326 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
NFJ87_RS01355 (280376) 280376..280954 - 579 WP_279270529.1 4'-phosphopantetheinyl transferase AcpT -
NFJ87_RS01360 (281017) 281017..282066 - 1050 WP_003023393.1 AI-2E family transporter -
NFJ87_RS01365 (282200) 282200..283417 + 1218 WP_230126762.1 MFS transporter -
NFJ87_RS01370 (283421) 283421..283978 - 558 WP_003837816.1 DcrB family lipoprotein -
NFJ87_RS01375 (284051) 284051..284716 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T248228 WP_003837806.1 NZ_CP099217:279183-279458 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT248228 WP_003837808.1 NZ_CP099217:279455-279814 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References