Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 829553..830207 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NFL15_RS04055 Protein ID WP_003026936.1
Coordinates 829800..830207 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NFL15_RS04050 Protein ID WP_003026938.1
Coordinates 829553..829819 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS04025 (824754) 824754..826187 - 1434 WP_279279148.1 6-phospho-beta-glucosidase BglA -
NFL15_RS04030 (826308) 826308..827036 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFL15_RS04035 (827089) 827089..827400 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
NFL15_RS04040 (827563) 827563..828222 + 660 WP_003026947.1 hemolysin III family protein -
NFL15_RS04045 (828316) 828316..829296 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
NFL15_RS04050 (829553) 829553..829819 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NFL15_RS04055 (829800) 829800..830207 + 408 WP_003026936.1 protein YgfX Toxin
NFL15_RS04060 (830252) 830252..830773 - 522 WP_003026933.1 flavodoxin FldB -
NFL15_RS04065 (830888) 830888..831784 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
NFL15_RS04070 (831808) 831808..832521 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFL15_RS04075 (832527) 832527..834260 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T248174 WP_003026936.1 NZ_CP099037:829800-830207 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT248174 WP_003026938.1 NZ_CP099037:829553-829819 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References