Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1095920..1096540 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag ND013_RS05215 Protein ID WP_015571250.1
Coordinates 1095920..1096138 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag ND013_RS05220 Protein ID WP_006809850.1
Coordinates 1096166..1096540 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS05185 1091932..1092192 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
ND013_RS05190 1092195..1092335 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ND013_RS05195 1092332..1093042 - 711 WP_032670463.1 GNAT family protein -
ND013_RS05200 1093144..1094604 + 1461 WP_033486652.1 PLP-dependent aminotransferase family protein -
ND013_RS05205 1094576..1095043 - 468 WP_015571252.1 YlaC family protein -
ND013_RS05210 1095160..1095711 - 552 WP_015571251.1 maltose O-acetyltransferase -
ND013_RS05215 1095920..1096138 - 219 WP_015571250.1 HHA domain-containing protein Toxin
ND013_RS05220 1096166..1096540 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
ND013_RS05225 1097051..1100197 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
ND013_RS05230 1100220..1101413 - 1194 WP_126499173.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T248076 WP_015571250.1 NZ_CP098778:c1096138-1095920 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT248076 WP_006809850.1 NZ_CP098778:c1096540-1096166 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References