Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 31722..32452 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag ND013_RS00150 Protein ID WP_023302825.1
Coordinates 31722..32036 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A837FJX0
Locus tag ND013_RS00155 Protein ID WP_015570115.1
Coordinates 32036..32452 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS00130 27388..28473 + 1086 Protein_25 cellulase family glycosylhydrolase -
ND013_RS00135 28379..29563 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
ND013_RS00140 29739..30572 - 834 WP_015570117.1 DMT family transporter -
ND013_RS00145 30635..31081 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
ND013_RS00150 31722..32036 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
ND013_RS00155 32036..32452 + 417 WP_015570115.1 helix-turn-helix domain-containing protein Antitoxin
ND013_RS00160 32599..32697 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
ND013_RS00165 32804..34492 + 1689 WP_126498969.1 acetolactate synthase large subunit -
ND013_RS00170 34496..34783 + 288 WP_015570113.1 acetolactate synthase small subunit -
ND013_RS00175 34909..35502 + 594 WP_003861054.1 transcriptional regulator UhpA -
ND013_RS00180 35499..37004 + 1506 WP_126498970.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T248074 WP_023302825.1 NZ_CP098778:31722-32036 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15367.95 Da        Isoelectric Point: 5.7670

>AT248074 WP_015570115.1 NZ_CP098778:32036-32452 [Enterobacter hormaechei]
MIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISRYEANRPEIVALRKEMESVPVGI
AVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FJX0

References