Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1106582..1107205 Replicon chromosome
Accession NZ_CP098719
Organism Yersinia ruckeri strain NVI-11267

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag ND445_RS05010 Protein ID WP_038243726.1
Coordinates 1106582..1106785 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag ND445_RS05015 Protein ID WP_004718732.1
Coordinates 1106837..1107205 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND445_RS04985 (ND445_04985) 1102437..1102775 + 339 WP_007886947.1 P-II family nitrogen regulator -
ND445_RS04990 (ND445_04990) 1102814..1104103 + 1290 WP_004718723.1 ammonium transporter AmtB -
ND445_RS04995 (ND445_04995) 1104218..1105081 - 864 WP_004718726.1 acyl-CoA thioesterase II -
ND445_RS05000 (ND445_05000) 1105459..1105773 - 315 WP_004718728.1 MGMT family protein -
ND445_RS05010 (ND445_05010) 1106582..1106785 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
ND445_RS05015 (ND445_05015) 1106837..1107205 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
ND445_RS05020 (ND445_05020) 1108254..1108415 + 162 WP_004718735.1 hypothetical protein -
ND445_RS05025 (ND445_05025) 1108534..1108677 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
ND445_RS05030 (ND445_05030) 1108697..1108951 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T247886 WP_038243726.1 NZ_CP098719:c1106785-1106582 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT247886 WP_004718732.1 NZ_CP098719:c1107205-1106837 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References