Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2565951..2566538 Replicon chromosome
Accession NC_014216
Organism Desulfurivibrio alkaliphilus AHT2

Toxin (Protein)


Gene name higB Uniprot ID D6Z6A0
Locus tag DAAHT2_RS11165 Protein ID WP_013164379.1
Coordinates 2565951..2566232 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag DAAHT2_RS11170 Protein ID WP_013164380.1
Coordinates 2566248..2566538 (+) Length 97 a.a.

Genomic Context

DAAHT2_RS14725DAAHT2_RS11165DAAHT2_RS11170DAAHT2_RS11175DAAHT2_RS11155DAAHT2_RS11160DAAHT2_RS11180DAAHT2_RS11185DAAHT2_RS11190DAAHT2_RS11195
Location: 2565598..2565852 (255 bp)
Type: Others
Protein ID: WP_157861473.1
Location: 2565951..2566232 (282 bp)
Type: Toxin
Protein ID: WP_013164379.1
Location: 2566248..2566538 (291 bp)
Type: Antitoxin
Protein ID: WP_013164380.1
Location: 2566578..2567294 (717 bp)
Type: Others
Protein ID: WP_013164381.1
Location: 2561876..2563870 (1995 bp)
Type: Others
Protein ID: WP_013164377.1
Location: 2564131..2565435 (1305 bp)
Type: Others
Protein ID: WP_013164378.1
Location: 2567315..2568742 (1428 bp)
Type: Others
Protein ID: WP_013164382.1
Location: 2568776..2569225 (450 bp)
Type: Others
Protein ID: WP_013164383.1
Location: 2569212..2569679 (468 bp)
Type: Others
Protein ID: WP_013164384.1
Location: 2569783..2571279 (1497 bp)
Type: Others
Protein ID: WP_013164385.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DAAHT2_RS111552561876..2563870-1995WP_013164377.1acetate--CoA ligase-
DAAHT2_RS111602564131..2565435-1305WP_013164378.1porin-
DAAHT2_RS147252565598..2565852+255WP_157861473.1hypothetical protein-
DAAHT2_RS111652565951..2566232+282WP_013164379.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DAAHT2_RS111702566248..2566538+291WP_013164380.1HigA family addiction module antidote proteinAntitoxin
DAAHT2_RS111752566578..2567294+717WP_013164381.1orotidine-5'-phosphate decarboxylase-
DAAHT2_RS111802567315..2568742-1428WP_013164382.1FAD-binding protein-
DAAHT2_RS111852568776..2569225-450WP_013164383.1hypothetical protein-
DAAHT2_RS111902569212..2569679-468WP_013164384.1PTS sugar transporter subunit IIA-
DAAHT2_RS111952569783..2571279-1497WP_013164385.1RNA polymerase factor sigma-54-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10830.43 Da        Isoelectric Point: 10.4524

>T24781 WP_013164379.1 NC_014216:2565951-2566232 [Desulfurivibrio alkaliphilus AHT 2]
MIVSIKDSETAKVWAGYFSRKLPTSIQAVARRKLRMINNARAIDDLRIPPANRLEKLSGNRAGQWSIRINDQWRICFTWN
NGQVEQVEICDYH

Download         Length: 282 bp

>T24781 NC_014216:2565951-2566232 [Desulfurivibrio alkaliphilus AHT 2]
ATGATTGTCTCTATCAAGGACAGTGAAACGGCCAAAGTTTGGGCGGGCTATTTTTCTCGCAAACTGCCAACTTCCATTCA
GGCGGTTGCTCGGCGGAAGTTGAGAATGATTAACAACGCTCGGGCAATTGATGATCTGCGAATTCCGCCCGCAAATCGCC
TGGAAAAGCTTTCCGGTAACCGGGCCGGCCAGTGGAGCATCAGAATCAACGACCAATGGCGAATATGCTTTACCTGGAAC
AACGGCCAGGTCGAGCAGGTTGAGATTTGCGATTACCATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10336.88 Da        Isoelectric Point: 6.9783

>AT24781 WP_013164380.1 NC_014216:2566248-2566538 [Desulfurivibrio alkaliphilus AHT 2]
MERLPNIHPGEVLREEFLKPLGISQYRLAKAIGVSPMRISEICAGKRSVTADSAIRLARALGTTPGFWLGLQADYDTEEA
INAAGNTLDAISRLAA

Download         Length: 291 bp

>AT24781 NC_014216:2566248-2566538 [Desulfurivibrio alkaliphilus AHT 2]
ATGGAAAGACTTCCCAACATCCACCCCGGTGAGGTTTTGCGCGAAGAGTTCCTTAAGCCTTTGGGCATCAGTCAGTACCG
ACTGGCCAAAGCCATCGGGGTATCACCCATGCGAATCAGCGAGATTTGCGCCGGCAAGCGCTCGGTTACCGCCGACAGCG
CCATCAGGCTGGCCCGGGCGCTGGGAACCACTCCCGGTTTCTGGCTGGGCCTGCAAGCCGACTACGACACCGAAGAGGCC
ATCAACGCCGCCGGCAACACCCTGGACGCCATCAGTCGGCTGGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD6Z6A0

Antitoxin

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Source
ID
Structure
No matching records found

References