Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2558008..2559596 Replicon chromosome
Accession NZ_CP098343
Organism Klebsiella pneumoniae strain 53009_G1

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NB668_RS12465 Protein ID WP_002904792.1
Coordinates 2558274..2559596 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NB668_RS12460 Protein ID WP_002904790.1
Coordinates 2558008..2558274 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB668_RS12435 (NB668_12435) 2553158..2554081 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NB668_RS12440 (NB668_12440) 2554062..2555216 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NB668_RS12445 (NB668_12445) 2555562..2556941 + 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NB668_RS12450 (NB668_12450) 2556919..2557419 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NB668_RS12455 (NB668_12455) 2557416..2557742 + 327 WP_002904788.1 hydroxyisourate hydrolase -
NB668_RS12460 (NB668_12460) 2558008..2558274 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NB668_RS12465 (NB668_12465) 2558274..2559596 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NB668_RS12470 (NB668_12470) 2559613..2560905 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NB668_RS12475 (NB668_12475) 2561047..2562051 - 1005 WP_002904798.1 fimbrial protein -
NB668_RS12480 (NB668_12480) 2562039..2564540 - 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T247489 WP_002904792.1 NZ_CP098343:2558274-2559596 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT247489 WP_002904790.1 NZ_CP098343:2558008-2558274 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References