Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | KacT-ataR/DUF1778(antitoxin) |
| Location | 725108..725902 | Replicon | chromosome |
| Accession | NC_014121 | ||
| Organism | Enterobacter cloacae subsp. cloacae ATCC 13047 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | A0A7V7JFS7 |
| Locus tag | ECL_RS03505 | Protein ID | WP_013095427.1 |
| Coordinates | 725108..725629 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A5E1AP76 |
| Locus tag | ECL_RS03510 | Protein ID | WP_013095428.1 |
| Coordinates | 725633..725902 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECL_RS03480 | 720435..720596 | + | 162 | WP_013095422.1 | DUF1127 domain-containing protein | - |
| ECL_RS03485 | 720683..722071 | - | 1389 | WP_013095423.1 | PLP-dependent aminotransferase family protein | - |
| ECL_RS03490 | 722174..722653 | + | 480 | WP_013095424.1 | carboxymuconolactone decarboxylase family protein | - |
| ECL_RS03495 | 722640..723542 | - | 903 | WP_013095425.1 | LysR family transcriptional regulator | - |
| ECL_RS03500 | 723643..725058 | + | 1416 | WP_013095426.1 | aldehyde dehydrogenase family protein | - |
| ECL_RS03505 | 725108..725629 | - | 522 | WP_013095427.1 | GNAT family N-acetyltransferase | Toxin |
| ECL_RS03510 | 725633..725902 | - | 270 | WP_013095428.1 | DUF1778 domain-containing protein | Antitoxin |
| ECL_RS03515 | 726117..726440 | + | 324 | WP_013095429.1 | antibiotic biosynthesis monooxygenase | - |
| ECL_RS03520 | 726433..726831 | + | 399 | WP_013095430.1 | amino acid-binding protein | - |
| ECL_RS03525 | 726803..727498 | + | 696 | WP_013095431.1 | winged helix-turn-helix domain-containing protein | - |
| ECL_RS03530 | 727702..728172 | + | 471 | WP_013095432.1 | MarR family transcriptional regulator | - |
| ECL_RS03535 | 728169..729236 | + | 1068 | WP_095440265.1 | HlyD family secretion protein | - |
| ECL_RS03540 | 729226..730302 | + | 1077 | WP_013095434.1 | DUF2955 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19410.33 Da Isoelectric Point: 9.2434
>T24740 WP_013095427.1 NC_014121:c725629-725108 [Enterobacter cloacae subsp. cloacae ATCC 13047]
VNNMKIGIFSDDVEYDLSHFDCGEESLNTFLTAHLKRQHRGKFLRGYVLVASGEKPRVLGYYTLSGSCFEKAYLPSKTQQ
KRVPYKNVPSVTLGRLAIDKRFQGQGLGELLVTHALKTVYLASFAVGIHGIFVEALNDSAKNFYLKLGFIALQAENENTL
FLPTKTIERLFAD
VNNMKIGIFSDDVEYDLSHFDCGEESLNTFLTAHLKRQHRGKFLRGYVLVASGEKPRVLGYYTLSGSCFEKAYLPSKTQQ
KRVPYKNVPSVTLGRLAIDKRFQGQGLGELLVTHALKTVYLASFAVGIHGIFVEALNDSAKNFYLKLGFIALQAENENTL
FLPTKTIERLFAD
Download Length: 522 bp
>T24740 NC_014121:c725629-725108 [Enterobacter cloacae subsp. cloacae ATCC 13047]
GTGAATAACATGAAAATAGGGATTTTTTCAGATGACGTTGAGTATGATCTAAGCCATTTCGATTGCGGAGAAGAGAGCCT
AAACACCTTTCTGACGGCGCACCTGAAACGCCAGCATCGTGGGAAATTTTTGCGGGGTTACGTTCTTGTCGCATCCGGGG
AAAAGCCGCGGGTGTTGGGTTATTACACGCTGTCCGGGAGCTGCTTTGAAAAGGCGTACCTTCCTTCTAAAACCCAGCAG
AAGCGAGTGCCTTACAAAAATGTTCCCAGCGTCACGCTGGGCCGCCTGGCGATTGATAAACGCTTCCAGGGGCAAGGATT
GGGGGAGTTGCTGGTCACCCATGCTCTGAAAACGGTCTACCTGGCGTCTTTTGCCGTGGGTATCCATGGGATATTCGTAG
AAGCGCTGAACGACAGCGCCAAAAACTTTTACCTTAAACTGGGGTTTATCGCCCTTCAGGCAGAGAATGAAAATACTCTC
TTCCTGCCGACTAAAACCATCGAAAGACTGTTTGCAGATTAA
GTGAATAACATGAAAATAGGGATTTTTTCAGATGACGTTGAGTATGATCTAAGCCATTTCGATTGCGGAGAAGAGAGCCT
AAACACCTTTCTGACGGCGCACCTGAAACGCCAGCATCGTGGGAAATTTTTGCGGGGTTACGTTCTTGTCGCATCCGGGG
AAAAGCCGCGGGTGTTGGGTTATTACACGCTGTCCGGGAGCTGCTTTGAAAAGGCGTACCTTCCTTCTAAAACCCAGCAG
AAGCGAGTGCCTTACAAAAATGTTCCCAGCGTCACGCTGGGCCGCCTGGCGATTGATAAACGCTTCCAGGGGCAAGGATT
GGGGGAGTTGCTGGTCACCCATGCTCTGAAAACGGTCTACCTGGCGTCTTTTGCCGTGGGTATCCATGGGATATTCGTAG
AAGCGCTGAACGACAGCGCCAAAAACTTTTACCTTAAACTGGGGTTTATCGCCCTTCAGGCAGAGAATGAAAATACTCTC
TTCCTGCCGACTAAAACCATCGAAAGACTGTTTGCAGATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10177.54 Da Isoelectric Point: 5.8652
>AT24740 WP_013095428.1 NC_014121:c725902-725633 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MSALKKQRIDLRLTEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIEQHRRLILNEASWNQVMDAISNPPTPNERLKR
AARRLQDLE
MSALKKQRIDLRLTEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIEQHRRLILNEASWNQVMDAISNPPTPNERLKR
AARRLQDLE
Download Length: 270 bp
>AT24740 NC_014121:c725902-725633 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGTCAGCACTAAAGAAACAGCGCATCGATCTACGCTTAACCGAAGACGACAAAAGCCTGATCGAAGAAGCAGCGGCAAT
GACGAACCAGTCAATTTCACAATTCATGGTAAGTACAGCCTCCGAGCGCGCAGCAGAAGTGATTGAACAGCACCGCCGCC
TGATCCTCAACGAGGCATCATGGAACCAGGTGATGGATGCGATCAGTAACCCGCCAACGCCAAATGAACGACTGAAGCGA
GCAGCCAGGCGTCTCCAGGATCTGGAGTGA
ATGTCAGCACTAAAGAAACAGCGCATCGATCTACGCTTAACCGAAGACGACAAAAGCCTGATCGAAGAAGCAGCGGCAAT
GACGAACCAGTCAATTTCACAATTCATGGTAAGTACAGCCTCCGAGCGCGCAGCAGAAGTGATTGAACAGCACCGCCGCC
TGATCCTCAACGAGGCATCATGGAACCAGGTGATGGATGCGATCAGTAACCCGCCAACGCCAAATGAACGACTGAAGCGA
GCAGCCAGGCGTCTCCAGGATCTGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7V7JFS7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E1AP76 |