Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4128480..4128892 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag KFZ60_RS19910 Protein ID WP_000132601.1
Coordinates 4128551..4128892 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4128480..4128556 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS19900 (4125343) 4125343..4126932 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
KFZ60_RS19905 (4126929) 4126929..4128323 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (4128480) 4128480..4128556 - 77 NuclAT_13 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_13 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_13 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_13 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_14 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_14 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_14 - Antitoxin
- (4128480) 4128480..4128556 - 77 NuclAT_14 - Antitoxin
KFZ60_RS19910 (4128551) 4128551..4128892 + 342 WP_000132601.1 endoribonuclease SymE Toxin
KFZ60_RS19915 (4129054) 4129054..4130433 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
KFZ60_RS19920 (4130433) 4130433..4131479 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4126929..4137178 10249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T247309 WP_000132601.1 NZ_CP098231:4128551-4128892 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT247309 NZ_CP098231:c4128556-4128480 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References