247254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2310519..2311045 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KFZ54_RS11170 Protein ID WP_000323025.1
Coordinates 2310758..2311045 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KFZ54_RS11165 Protein ID WP_000534858.1
Coordinates 2310519..2310758 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS11135 (2305881) 2305881..2306370 + 490 Protein_2176 class I SAM-dependent methyltransferase -
KFZ54_RS11140 (2306848) 2306848..2307269 + 422 Protein_2177 hypothetical protein -
KFZ54_RS11145 (2307925) 2307925..2308995 + 1071 Protein_2178 ISNCY family transposase -
KFZ54_RS11150 (2309068) 2309068..2309217 + 150 WP_011443592.1 protein YdfW -
KFZ54_RS11155 (2309654) 2309654..2309986 - 333 WP_001301033.1 FlxA-like family protein -
KFZ54_RS11160 (2310189) 2310189..2310494 - 306 WP_001326990.1 protein YdfV -
KFZ54_RS11165 (2310519) 2310519..2310758 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KFZ54_RS11170 (2310758) 2310758..2311045 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KFZ54_RS11175 (2311117) 2311117..2311272 + 156 WP_088376227.1 type I toxin-antitoxin system toxin HokD -
KFZ54_RS11180 (2311489) 2311489..2311740 + 252 WP_000980994.1 protein Rem -
KFZ54_RS11185 (2311807) 2311807..2312085 + 279 WP_012304870.1 hypothetical protein -
KFZ54_RS11190 (2312087) 2312087..2313136 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KFZ54_RS11195 (2313150) 2313150..2313902 + 753 WP_001047135.1 antitermination protein -
KFZ54_RS11200 (2314180) 2314180..2314269 - 90 WP_120795389.1 hypothetical protein -
KFZ54_RS11205 (2314324) 2314324..2314536 - 213 WP_000087756.1 cold shock-like protein CspF -
KFZ54_RS11210 (2314837) 2314837..2315052 + 216 WP_000066484.1 cold shock-like protein CspB -
KFZ54_RS11215 (2315416) 2315416..2315586 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KFZ54_RS11220 (2315806) 2315806..2316021 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2290074..2329579 39505


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T247254 WP_000323025.1 NZ_CP098227:2310758-2311045 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT247254 WP_000534858.1 NZ_CP098227:2310519-2310758 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References