Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4068221..4068875 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NBY14_RS19285 Protein ID WP_000244781.1
Coordinates 4068221..4068628 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag NBY14_RS19290 Protein ID WP_001564007.1
Coordinates 4068609..4068875 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS19265 (4064178) 4064178..4065911 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
NBY14_RS19270 (4065917) 4065917..4066627 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY14_RS19275 (4066652) 4066652..4067548 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY14_RS19280 (4067660) 4067660..4068181 + 522 WP_001055874.1 flavodoxin FldB -
NBY14_RS19285 (4068221) 4068221..4068628 - 408 WP_000244781.1 protein YgfX Toxin
NBY14_RS19290 (4068609) 4068609..4068875 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
NBY14_RS19295 (4069118) 4069118..4070098 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
NBY14_RS19300 (4070175) 4070175..4070834 - 660 WP_000250274.1 hemolysin III family protein -
NBY14_RS19305 (4070998) 4070998..4071309 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
NBY14_RS19310 (4071354) 4071354..4072787 + 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T247174 WP_000244781.1 NZ_CP098217:c4068628-4068221 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT247174 WP_001564007.1 NZ_CP098217:c4068875-4068609 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References