Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2552731..2553293 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag NBY15_RS12550 Protein ID WP_000605675.1
Coordinates 2552731..2553009 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NBY15_RS12555 Protein ID WP_000781370.1
Coordinates 2553009..2553293 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS12525 (2548317) 2548317..2548748 - 432 WP_000152305.1 peroxiredoxin OsmC -
NBY15_RS12530 (2549093) 2549093..2549308 + 216 WP_000495766.1 biofilm-dependent modulation protein -
NBY15_RS12535 (2549410) 2549410..2549547 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
NBY15_RS12540 (2549704) 2549704..2551401 + 1698 WP_000433464.1 malate dehydrogenase -
NBY15_RS12545 (2551535) 2551535..2552545 + 1011 WP_021560663.1 alcohol dehydrogenase AdhP -
NBY15_RS12550 (2552731) 2552731..2553009 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY15_RS12555 (2553009) 2553009..2553293 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NBY15_RS12560 (2553522) 2553522..2554175 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
NBY15_RS12565 (2554168) 2554168..2555052 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
NBY15_RS12570 (2555065) 2555065..2558112 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T247131 WP_000605675.1 NZ_CP098214:2552731-2553009 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT247131 WP_000781370.1 NZ_CP098214:2553009-2553293 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References