Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 574027..574622 Replicon chromosome
Accession NZ_CP098201
Organism Escherichia coli strain Z0117EC0056

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag NBY20_RS02705 Protein ID WP_019842229.1
Coordinates 574272..574622 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NBY20_RS02700 Protein ID WP_001223213.1
Coordinates 574027..574278 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY20_RS02690 (569692) 569692..573471 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
NBY20_RS02695 (573474) 573474..573815 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
NBY20_RS02700 (574027) 574027..574278 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NBY20_RS02705 (574272) 574272..574622 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
NBY20_RS02710 (574826) 574826..575356 - 531 WP_000055075.1 inorganic diphosphatase -
NBY20_RS02715 (575666) 575666..576622 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NBY20_RS02720 (576754) 576754..578256 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
NBY20_RS02725 (578270) 578270..579292 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T247001 WP_019842229.1 NZ_CP098201:574272-574622 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT247001 WP_001223213.1 NZ_CP098201:574027-574278 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References