Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1896802..1897603 Replicon chromosome
Accession NZ_CP098195
Organism Escherichia coli strain Z0117EC0098

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag NBY23_RS09525 Protein ID WP_000854739.1
Coordinates 1897223..1897603 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NBY23_RS09520 Protein ID WP_021560693.1
Coordinates 1896802..1897176 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY23_RS09480 (1892814) 1892814..1893269 + 456 WP_000581502.1 IrmA family protein -
NBY23_RS09485 (1893412) 1893412..1893501 + 90 WP_112031555.1 DUF905 family protein -
NBY23_RS09490 (1893680) 1893680..1894501 + 822 WP_021560695.1 DUF932 domain-containing protein -
NBY23_RS09495 (1894501) 1894501..1894746 + 246 WP_001164966.1 hypothetical protein -
NBY23_RS09500 (1894840) 1894840..1895313 + 474 WP_001542276.1 antirestriction protein -
NBY23_RS09505 (1895329) 1895329..1895805 + 477 WP_001186170.1 RadC family protein -
NBY23_RS09510 (1895868) 1895868..1896089 + 222 WP_000692315.1 DUF987 domain-containing protein -
NBY23_RS09515 (1896108) 1896108..1896752 + 645 WP_021560694.1 hypothetical protein -
NBY23_RS09520 (1896802) 1896802..1897176 + 375 WP_021560693.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY23_RS09525 (1897223) 1897223..1897603 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
NBY23_RS09530 (1897600) 1897600..1898088 + 489 WP_001054232.1 DUF5983 family protein -
NBY23_RS09535 (1898108) 1898108..1898305 + 198 WP_000772027.1 DUF957 domain-containing protein -
NBY23_RS09540 (1898390) 1898390..1899233 + 844 Protein_1871 DUF4942 domain-containing protein -
NBY23_RS09550 (1899724) 1899724..1899942 - 219 WP_001040187.1 translation initiation factor IF-1 -
NBY23_RS09555 (1900227) 1900227..1900931 - 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T246942 WP_000854739.1 NZ_CP098195:1897223-1897603 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13863.51 Da        Isoelectric Point: 4.5940

>AT246942 WP_021560693.1 NZ_CP098195:1896802-1897176 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWELPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure

References